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Biography
Dr K Miraz Rahman (KMR) is a Professor in Medicinal Chemistry at the School of Cancer & Pharmaceutical Sciences, King’s College London. After working three years in the industry, he went back to academia and obtained his PhD from the UCL School of Pharmacy in synthetic medicinal chemistry. KMR’s research activities are focused on the application of advanced computational chemistry, synthetic medicinal chemistry and chemical biology techniques to the design, synthesis and evaluation of novel drug-like chemical scaffolds as anticancer and anti-infective agents. He is the author of over 80 research publications, inventor on 14 patents and has more than 15 years of research experience in medicinal chemistry and biophysical techniques. Dr Rahman has been working on pyrrolobenzodiazepine-based DNA binding agents for the past 14 years and has developed PBD-based anticancer and antibacterial agents that have been patented and licensed to university spin-out companies. He is working with Public Health England to develop chemical tools to study antimicrobial resistance (AMR) and discover new ways to target multiple drug-resistant pathogens. He has used a combination of homology modelling and advanced computational calculations to study bacterial efflux pumps and has invented a new class of antibiotic resistance breakers (ARBs) that are currently being commercialised. The Rahman laboratory is located on the 5th floor of the Franklin Wilkins Building at King’s College London and is funded by grants from industry, charities and research councils. He has experience in early and late-stage drug discovery, and translational research, co-founding oncology biotech companies Transcriptogen Ltd (2013) and Femtogenix Ltd (2015).
Latest publications
Latest publications
Efflux pumps in Mycobacterium tuberculosis and their inhibition to tackle antimicrobial resistanceLaws, M., Jin, P. & Rahman, K. M., Jan 2022, In: Trends in Microbiology. 30, 1, p. 57-68 12 p. Research output: Contribution to journal › Review article › peer-review. DOIs: https://doi.org/10.1016/j.tim.2021.05.001
Indole alkaloids from the leaves of Ravenia spectabilis engl. with activity against pancreatic cancer cell lineTabassum, F., Hasan, C. M., Masud, M. M., Jamshidi, S., Rahman, K. M. & Ahsan, M., Jun 2021, In: PHYTOCHEMISTRY. 186, 112744. Research output: Contribution to journal – Article – peer-review. DOIs: https://doi.org/10.1016/j.phytochem.2021.112744
A New Cyclohexanone Derivative from the Leaves of Bridelia stipularisShahriar, K. R., Hossain, M. E., Rahman, K. M., Ahsan, M. & Hasan, C. M., May 2021, In: Chemistry of Natural Compounds. 57, 3, p. 455-458 4 p. Research output: Contribution to journal – Article – peer-review. DOIs: https://doi.org/10.1007/s10600-021-03386-y
Antibody-drug conjugates—a tutorial reviewBaah, S., Laws, M. & Rahman, K. M., May 2021, In: Molecules. 26, 10, 2943. Research output: Contribution to journal – Review article – peer-review. DOIs: https://doi.org/10.3390/molecules26102943
Development of photoactivable phenanthroline-based manganese(I) CO-Releasing molecules (PhotoCORMs) active against ESKAPE bacteria and bacterial biofilmsToscani, A., Hind, C., Clifford, M., Kim, S. H., Gucic, A., Woolley, C., Saeed, N., Rahman, K. M., Sutton, J. M. & Castagnolo, D., 5 Mar 2021, In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 213, 113172. Research output: Contribution to journal – Article – peer-review. DOIs: https://doi.org/10.1016/j.ejmech.2021.113172
Therapeutic intervention of COVID-19 by natural products: A population-specific survey directed approachGomez, C. R., Espinoza, I., Faruque, F. S., Hasan, M. M., Rahman, K. M., Walker, L. A. & Muhammad, I., Feb 2021, In: Molecules. 26, 4, 1191. Research output: Contribution to journal – Review article – peer-review. DOIs: https://doi.org/10.3390/molecules26041191
Whole Genome Sequencing of Staphylococcus aureus SA-1199B Reveals Previously Unreported MutationsLaws, M., Rahman, M., Hind, C. K., Sutton, M. & Wand, M. E., Jan 2021, In: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS. 57, 1, p. 1-2 2 p., 106225. Research output: Contribution to journal – Letter – peer-review. DOIs: https://doi.org/10.1016/j.ijantimicag.2020.106225
Efflux pumps in Mycobacterium tuberculosis and their inhibition to tackle antimicrobial resistanceLaws, M., Jin, P. & Rahman, K. M., 2021, (Accepted/In press) In: Trends in Microbiology. Research output: Contribution to journal – Review article – peer-review. DOIs: https://doi.org/10.1016/j.tim.2021.05.001
The KDM5B protein expressed in the viable and fertile ΔARID mouse has no demethylase activityJamshidi, S., Catchpole, S., Chen, J., So, C. W. E., Burchell, J., Rahman, M. & Taylor-Papadimitriou, J., 2021, In: International Journal of Oncology. Research output: Contribution to journal – Article – peer-review
Antimicrobial Constituents from Machaerium Pers.: Inhibitory Activities and Synergism of Machaeriols and Machaeridiols against Methicillin-Resistant Staphylococcus aureus, Vancomycin-Resistant Enterococcus faecium, and Permeabilized Gram-Negative PathogensIlias, M., Jacob, M. R., Ibrahim, M. A., Raman, V., Kumarihamy, M., Wang, M., Al-Adhami, T., Hind, C., Clifford, M., Martin, B., Zhao, J., Sutton, J. M. & Rahman, M., 18 Dec 2020, In: Molecules (Basel, Switzerland). p. 1-14 14 p., 6000. Research output: Contribution to journal – Article – peer-review
Integron gene cassettes harboring novel variants of d-alanine-d-alanine ligase confer high-level resistance to d-cycloserineRahman, M. A., Kaiser, F., Jamshidi, S., Freitas Monteiro, M., Rahman, K. M., Mullany, P. & Roberts, A. P., Dec 2020, In: Scientific Reports. 10, 1, 20709. Research output: Contribution to journal – Article – peer-review. DOIs: https://doi.org/10.1038/s41598-020-77377-4
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